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pentobarbital will reduce the level or outcome of ethotoin by impacting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.pentobarbital decreases consequences of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may reduce sufentanil ranges and efficacy,